BIOINFORMATICS & DATA INTERPRETATION
From clonal structure to cellular states and tissue context: organize data, figures and interpretation around the research question.
BIOINFORMATICS
Clones, cellular states and tissue context.
Different perspectives on your research question.
DNA · CLONAL STRUCTURE
Start with single-cell copy-number profiles to compare subclones, shared events and changes across research time points.
RNA · CELLULAR STATES
Connect cell-type identification with marker expression, composition and differential analysis to study cellular states.
SPACE · TISSUE CONTEXT
Interpret cell types, regional differences and neighborhoods in tissue coordinates, with clonal integration planned around matched material.
NETWORKS · CANDIDATE MECHANISMS
Use cell relationships, communication and regulatory-network analysis to prioritize questions for follow-up mechanistic work.
SINGLE-CELL TRANSCRIPTOMICS
Organize analysis around cell identity, heterogeneity, relationships and regulation.
Build a cellular overview from embeddings, markers and composition.
Compare differential expression, pathway enrichment and states.
Use cellular states and trajectories to develop testable hypotheses.
Prioritize factors associated with cell identity and state changes.
Example: CNKINGBIO single-cell brochure · page 2 · Figures illustrate analysis categories; applicable data and scope are agreed per project.
SPATIAL TRANSCRIPTOMICS
Connect cell types, regional differences and regulation in tissue coordinates.
Review cell-type distributions within tissue regions.
Compare expression patterns across regions and cell groups.
Analyze cellular neighborhoods and regional relationships.
Associate candidate regulatory programs with tissue regions.
Example: CNKINGBIO spatial brochure · page 2 · Figures illustrate analysis categories; applicable data and scope are agreed per project.
ANALYSIS DELIVERABLES
Select the analysis around your question and agree on deliverables in the study plan.
Sample and data QC, annotation notes, core result tables and analysis version information.
Agreed clonal, expression, spatial or network figures, with clear datasets and group definitions.
Interpret results within the study design and discuss validation, cohort expansion and follow-up work.
PLAN YOUR ANALYSIS
Bring a sample overview, existing data and research goals to discuss the analysis plan.
