RESEARCH APPLICATIONS
From archival cohorts to same-cell mechanistic evidence, then spatial and functional validation. Find a clear path to the next experiment.
CHOOSE THE QUESTION, THEN THE ASSAY
These are research scenarios and study-design examples, not clinical diagnostic indications.
Which clonal relationships persist from primary disease to recurrence?
DNA-level validation of candidate CNAs and independent-case replication.
Does treatment change clonal composition, cell state, or both?
Account for regimens, sampling bias and pathology response; not an individual treatment recommendation.
Which normal-lineage signals are retained by ancestral clones?
Tissue localization, markers and functional studies; origin signals are hypotheses, not proof.
Which expression programs associate with a CNA-defined subclone?
Genetic perturbation, protein assays and external cohorts; distinguish association from causation.
Where might a candidate clone reside, and which cells surround it?
Clone-specific CNA, FISH or suitable in situ validation of localization.
Which clones are retained in a model, and how do they change with perturbation?
Use independent replicates and appropriate controls; model drug response is not patient efficacy.
DESIGN EXAMPLE · NOT A COMPLETED CUSTOMER CASE
The following extends platform capabilities into a study design. It is not a completed customer case or dataset.
Compare paired DNA data before and after intervention for evidence of clonal selection.
Use wellDR-seq in suitable fresh specimens to relate clones to transcriptional programs.
Test candidate genes in independent models and use spatial or pathology data to explore environmental factors.
LET’S BUILD YOUR STUDY
Bring your sample type, research question and existing data. Let’s find the right starting point.
